颅内外动脉粥样硬化性大动脉狭窄与脑梗死关系   总被引：1，自引：0，他引：1  

潘妍婷  邹玉安 《河北北方学院学报(医学版)》2005,22(2):46-48

目的:探讨动脉粥样硬化性颈动脉狭窄、颅内大脑中动脉狭窄与急性脑梗死的关系及脑梗死复发原因.方法:采用多普勒超声对136例急性脑梗死患者进行颅内外动脉检测,并对随访期间复发患者进行动脉彩色多普勒超声检测分析.结果:136例脑梗死患者大脑中动脉狭窄42例,颈动脉中、重度狭窄12例.随访期内脑梗死复发26例,其中颈动脉中、重度狭窄10例.结论:急性脑梗死与大脑中动脉严重狭窄者密切相关,复发性脑梗死与颈动脉狭窄密切相关.  相似文献   

无脑儿心脏的组织学观察与比较     

付学清  梅盛平  万能章  雷天晓 《孝感职业技术学院学报》2006,9(2):80-81

目的:探讨无脑儿与正常胎儿心脏结构的差异,为畸形胎儿的心脏发育研究提供形态学方面的资料。方法:用H.E染色,通过光镜观察无脑儿及正常胎儿的心脏结构。结果:无脑儿心脏的蒲肯野细胞数量明显低于同龄正常胎儿。结论:无脑儿神经系统发育异常影响其心脏内蒲肯野细胞的发育。  相似文献   

脂蛋白(a)与脑梗塞的关系     

阎智宏  梁庆智  张效云  董明纲  孙敏 《河北北方学院学报(医学版)》2001,18(2):41-42

目的研究脑梗塞患者血浆脂蛋白(a)水平.方法以酶联免疫吸附法(ELISA)测定44例脑梗塞患者与38名健康人血浆脂蛋白(a)浓度.结果脑梗塞患者的脂蛋白(a)浓度显著高于正常健康人.结论血浆高脂蛋白(a)水平是脑梗塞的重要危险因素.  相似文献   

藻酸双脂钠对急性脑梗死患者纤维蛋白原、脂蛋白(a)的影响及疗效观察     

潘妍婷  赵宏  雷霞 《河北北方学院学报(医学版)》2007,24(1):22-24

目的：探讨藻酸双脂钠（PSS）治疗急性脑梗死患者血液成分变化及疗效。方法：急性脑梗死患者158例，随机分为两组。对照组：78例，常规治疗；治疗组：80例，在常规治疗基础上，应用藻酸双脂钠注射液100mg加入0．9％氯化钠静脉滴注，每日一次，连续观察14d。对比分析二组治疗前后脂蛋白（a）、血脂、纤维蛋白原等血液流变学指标．并动态观察治疗前后临床神经功能缺损评分。结果：藻酸双脂钠可降低全血粘度、血浆粘度、血小板聚集率、纤维蛋白原及血清TC、TG、LDL，与治疗前比较有显著性改变（P〈0．01或P〈0．05）；与对照组比较有显著性差异（P〈0．01或P〈0．05）．但对脂蛋白（a）无影响；近期预后较常规治疗组好（P〈0．05）．结论：藻酸双脂钠可改善血液高粘滞状态，起到降低纤维蛋白原、抗血小板聚集作用，可改善近期临床神经功能缺损程度。  相似文献   

Allograftic bone marrow-derived mesenchymal stem cells transplanted into heart infarcted model of rabbit to renovate infarcted heart     

王建安  李长岭  樊友启  何红  孙勇 《浙江大学学报(A卷英文版)》2004,5(10):1279-1285

Objective: To investigate the directed transplantation of allograftic bone marrow-derived mesenchymal stem cells (MSCs) in myocardial infarcted (MI) model rabbits. Materials and Methods: Rabbits were divided into 3 groups, heart infarcted model with MSCs transplanted treatment (MSCs group, n=12), heart infarcted model with PBS injection (control group, n=20), sham operation with PBS injection (sham group, n=l 7). MSCs labelled by BrdUrd were injected into the MI area of the MSCs group. The same volume of PBS was injected into the MI area of the control group and sham group. The mortality, LVIDd, LVIDs and LVEF Of the two groups were compared 4 weeks later. Tropomyosin inhibitory component (Tn I) and BrdUrd immunohistochemistry identified the engrafted cells 4 weeks after transplantation. Result: The mortality of the MSCs group was 16.7% (2/12), and remarkably lower than the control group's mortality [35% (7/20) (P＜0.05)].Among the animals that survived for 4 weeks, the LVIDd and LVIDs of the MSCs group after operation were 1.17±0.21 cm and 0.74±0.13 cm, and remarkably lower than those of the model group, which were 1.64±0.14 cm and 1.19±0.12 cm (P＜0.05); the LVEF of the MSCs group after operation was 63±6%, and remarkably higher than that of the model group,which was 53±6% (P＜0.05). Among the 10 cases of animals that survived for 4 weeks in the MSCs group, in 8 cases (80%),the transplanted cells survived in the non MI, MI region and its periphery, and even farther away; part of them differentiated into cardiomyocytes; in 7 cases (70%), the transplanted cells participated in the formation of blood vessel tissue in the MI region. Conclusion: Transplanted allograftic MSCs can survive and differentiate into cardiomyocytes, form the blood vessels in the MI region. MSCs transplantation could improve the heart function after MI.  相似文献   

Cell therapy in congestive heart failure   总被引：5，自引：0，他引：5  

Tao ZW  Li LG 《Journal of Zhejiang University. Science. B》2007,8(9):647-660

Congestive heart failure （CHF） has emerged as a major worldwide epidemic and its main causes seem to be the aging of the population and the survival of patients with post-myocardial infarction. Cardiomyocyte dropout （necrosis and apoptosis） plays a critical role in the progress of CHF; thus treatment of CHF by exogenous cell implantation will be a promising medical approach. In the acute phase of cardiac damage cardiac stem cells （CSCs） within the heart divide symmetrically and/or asymmetrically in response to the change of heart homeostasis, and at the same time homing of bone marrow stem cells （BMCs） to injured area is thought to occur, which not only reconstitutes CSC population to normal levels but also repairs the heart by differentiation into cardiac tissue. So far, basic studies by using potential sources such as BMCs and CSCs to treat animat CHF have shown improved ventricular remodelling and heart function. Recently, however, a few of randomized, double-blind, placebo-controlled clinical trials demonstrated mixed results in heart failure with BMC therapy during acute myocardial infarction.  相似文献   

LONG-TERM INHIBITION OF Na~ /H~ EXCHANGE ATTENUATES CARDIAC REMODELING AFTER MYOCARDIAL INFARCTION IN RATS     

XIA Qin-gui  *L  Oliver Chung  Heidi Spitznagel  Thomas Unger 《Journal of Zhejiang University. Science. B》2001,(4)

ＩＮＴＲＯＤＵＣＴＩＯＮＴｈｅＮａ /Ｈ ｅｘｃｈａｎｇｅｒ (ＮＨＥ)ｉｓａｐＨ ｒｅｇｕｌａｔｏｒｙｐｒｏｔｅｉｎｐｒｅｓｅｎｔｉｎｔｈｅｐｌａｓｍａｍｅｍ ｂｒａｎｃｅｏｆｃａｒｄｉｏｍｙｏｃｙｔｅｓａｎｄｏｔｈｅｒｃｅｌｌｔｙｐｅｓ.ＡｌｔｈｏｕｇｈｓｅｖｅｒａｌｉｓｏｆｏｒｍｓｏｆＮＨＥｈａｖｅｂｅｅｎｄｅ ｃｒｉｂｅｄ,ｔｈｅｐｒｅｄｏｍｉｎａｎｔｉｓｏｆｏｒｍｉｎｔｈｅｈｅａｒｔｉｓｔｈｅｕｂｉｑｕｉｔｏｕｓＮＨＥ 1 ,ｗｈｉｃｈｕｎｄｅｒｃｅｎｔａｉｎｐｈｙｓｉｏｌｏｇｉｃａｌｃｏｎｄｉｔｉ…  相似文献   

小剂量尿激酶加法安明在脑梗塞早期的应用     

王建文 《河北北方学院学报(医学版)》2002,19(5):25-27

目的 :研究小剂量尿激酶和法安明在脑梗塞早期应用的临床疗效。方法 :将 10 8例脑梗塞患者分为三组 ,分别采用小剂量尿激酶治疗 (简称尿激酶组 ) ;小剂量尿激酶加法安明治疗 (简称联合组 ) ;传统疗法 (简称对照组 )。治疗前后采用欧洲卒中评分法进行神经功能评分。结果 :治疗前各组分数无显著性差异 ,治疗后联合组 >尿激酶组 >对照组 ,差异均有显著性。联合组的卒中继续进展及再梗塞发生率明显降低。结论 :小剂量尿激酶与法安明联用能有效阻止血栓进展 ,减少再梗塞 ,有利于神经功能恢复 ,疗效显著而无明显副作用。  相似文献   

有氧训练对一次力竭运动小鼠心肌及血清抗氧化酶的影响     

巩清波 《体育科技文献通报》2013,(11):28-29,42

目的：经过16周有氧训练,观察一次性力竭运动后小鼠心肌及血清抗氧化酶活性及过氧化脂质的变化,探讨长期有氧运动对运动应激时机体的抗氧化能力的影响。方法：36只雌性KM小鼠随即分成有氧训练组（E组）、运动应激组（0组）和空白对照组（c组）,E组经过16周有氧训练后与0组进行一次性力竭游泳实验,测定力竭运动后心肌和血清中MDA、SOD、CAT、T—AOC、CK等指标的变化。结果：小鼠经过力竭运动后心肌SOD、CAT、T—AOC含量,E组与0组相比增加非常显著（P〈0．01）。结论：经过16周的有氧训练后,小鼠对运动应激引起的氧化适应能力得到提高,小鼠的心脏组织和血清中脂质过氧化程度都有所下降。  相似文献   

Risk of cardiac rupture after acute myocardial infarction is related to a risk of hemorrhage     

Geng QIAN  Hong-bin LIU  Jin-wen WANG  Chen WU  Yun-dai CHEN 《Journal of Zhejiang University. Science. B》2013,14(8):736-742

Although cardiac rupture (CR) is a fatal mechanical complication of acute myocardial infarction (AMI), to date no predictive model for CR has been described. CR has common pathological characteristics with major bleeding. We aimed to investigate the relationship between the risk factors of major bleeding and CR. A total of 10 202 consecutive AMI patients were recruited, and mechanical complications occurred in 72 patients. AMI patients without CR were chosen as control group. Clinical characteristics including bleeding-related factors were compared between the groups. The incidences of free wall rupture (FWR), ventricular septal rupture (VSR), and papillary muscle rupture (PMR) were 0.39%, 0.21%, and 0.09%, respectively, and the hospital mortalities were 92.5%, 45.5%, and 10.0%, respectively. Female proportion and average age were significantly higher in the groups of FWR and VSR than in the control group (P<0.01); higher white blood cell count and lower hemoglobin were found in all CR groups (P<0.01). Compared to the control group, patients with CR were more likely to receive an administration of thrombolysis [26.39% vs. 13.19%, P<0.05], and were less likely to be treated with primary percutaneous coronary intervention (PCI) [41.67% vs. 81.60%, P<0.05]. The major bleeding scores (integer scores) of FWR, VSR, and PMR were (17.70±7.24), (21.91±8.33), and (18.60±7.88), respectively, and were significantly higher than that of the control group (11.72±7.71) (P<0.05). A regression analysis identified age, increased heart rate, anemia, higher white blood cell count, and thrombolysis as independent risk factors of CR, most of which were major bleeding-related factors. The patients with CR have a significantly higher risk of hemorrhage compared to the group without CR. Risk of CR after AMI is related to the risk of hemorrhage.  相似文献